Synthesis, spectroscopic characterization, biological screening and POM analysis of potentially bioactive copper(II) carboxylate complexes

ABSTRACT. Here we are reporting the synthesis, characterization of four novel copper(II) complexes with carboxylate ligand and their evaluation for biological applications. The have general formulas C22H18CuN4O12, C32H26CuN6O12, C27H23CuN5O12 C34H26CuN6O12. synthesized were characterized by FT-IR elemental analyses carried out through EDX. deprotonation ligand, 4-(2-methoxy-5-nitrophenylamino)-4-oxobut-2-enoic acid, was observed in spectrum, indicating that complexation happens via moiety's oxygen. In 1 3, value ?? is between 120-180 cm-1 showing bridging mode moiety while 2 4, its greater than 180 monodentate binding mode. findings antimicrobial activity revealed adequate antibacterial antifungal properties. anti-promastigote analysis results showed 4 significant as compared to standard drug. DNA confirmed UV-Visible spectroscopy viscosity measurements interact intercalative A new efficient strategy applied POM (Petra, Osiris Molinspiration) determining toxicity assessment, bio-availability drug score complexes. good bioavailability scores.
 
 KEY WORDS: Copper(II) complex, binding, Anti-promastigote analysis, Cytotoxicity, Docking study
 Bull. Chem. Soc. Ethiop. 2022, 36(1), 57-71. DOI: https://dx.doi.org/10.4314/bcse.v36i1.6